Skip to content

Talk at QUT on Friday August 7

August 6, 2015

Title: Lorentzian mixture model for Raman spectroscopy

Speaker: Matt Moores (University of Warwick, UK)

Date: Friday 7 August 2015

Time: 3:00pm – 4:00pm

Location: O603, Gardens Point Campus, Queensland University of Technology

Abstract: Surface-enhanced resonance Raman scattering (SERRS) is an optical spectroscopic technique for identifying labelled molecules. A SERRS signal can be represented as a mixture of Lorentzian peaks plus a smoothly-varying baseline due to background fluorescence. The multivariate observations are thus highly collinear and lend themselves to a reduced-rank representation. We introduce a sequential Monte Carlo algorithm for joint estimation of the baseline and peaks. Our model-based approach accounts for batch effects between technical replicates. By analysing a large number of Raman-active dyes with similar chemical structure, we can characterise how structural differences are represented as changes in the spectral signature. Our model can be used for identification and quantification of dye labels in a multiplex, as well as hierarchical clustering of dyes according to structural similarity.

This is joint work with Mark Girolami (Warwick), Kirsten Gracie, Karen Faulds and Duncan Graham (U. Strathclyde).

From → Functional Data

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Ella Kaye on Ella Kaye

Computational Bayesian statistics

Bayes' Food Cake

A bit of statistics, a bit of cakes. - Blogs to Learn R from the Community

Computational Bayesian statistics

Richard Everitt's blog

Computational Bayesian statistics

Let's Look at the Figures

David Firth's blog

Nicholas Tierney

Computational Bayesian statistics

Sweet Tea, Science

Two southern scientistas will be bringing you all that is awesome in STEM as we complete our PhDs. Ecology, statistics, sass.

Mad (Data) Scientist

Musings, useful code etc. on R and data science

Darren Wilkinson's blog

Statistics, computing, functional programming, data science, Bayes, stochastic modelling, systems biology and bioinformatics

(badness 10000)

Computational Bayesian statistics

Igor Kromin

Computational Bayesian statistics


I can't get no

Xi'an's Og

an attempt at bloggin, nothing more...

Sam Clifford

Postdoctoral Fellow, Bayesian Statistics, Aerosol Science

%d bloggers like this: